Christina Applegate breaks her silence following reports of hospitalization

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Christina Applegate is reassuring fans after reports of her hospitalization began circulating on April 16th.

“Thank you for the outpouring of love and blessings. Health issues are common for me, but I’m a strong chick and getting stronger and better each day,” the “Marry…and Kids” alum wrote in the caption of an April 20 Instagram post. “I’m taking some time to focus on my health, but I want to talk to you again soon.”

The message included a photo of a coffee mug resting on top of her memoir, “You with Sad Eyes,” on a balcony railing with lush trees in the background.

In an April 17 interview with USA TODAY, which was reported by TMZ, Applegate’s representative Ame Van Luden declined to comment on whether Applegate was hospitalized.

“As evidenced in her memoir and podcast, she has been refreshingly open about her long and complex medical history,” VanLurden told USA TODAY.

Applegate’s podcast MeSsy, which she co-hosts with fellow actress Jamie Lynn Sigler, who also has multiple sclerosis, went on a brief hiatus at the end of March. They announced that the podcast would be on a “short hiatus for the next few weeks” while Sigler and Applegate promote their book.

Christina Applegate’s multiple sclerosis symptoms

Applegate, who revealed her multiple sclerosis diagnosis in 2021, spoke about the impact the autoimmune disease has had on her health in recent years.

She revealed in a 2025 podcast episode that she has been hospitalized “over 30 times” since being diagnosed with MS. And symptoms such as mobility and balance issues, numbness and vision problems have made it difficult for her to appear in public.

“In January 2021, I was hiking and running and playing tennis. By June 2021, I couldn’t even walk anymore,” she told USA TODAY while promoting her 2026 memoir. In her book, she describes the symptoms as follows: “It’s like I have a brick stuck to my knee, it’s heavy and it hurts. My skin feels like I have third-, fourth-, and fifth-degree burns. There’s always something stuck in my ankle. I wake up and it feels like the floor is made of needles, but I can’t feel it because my leg is completely numb. Somehow I can do both at the same time.”

This chronic neurological disorder is characterized by the immune system attacking the myelin sheath, a “substance that surrounds and protects nerve cells,” causing damage that “slows or blocks messages between the brain and the body,” according to the National Library of Medicine.

Patients report vision problems. Muscle weakness in the limbs. Tingling, numbness, or pain in your arms, legs, torso, or face. Cognitive changes. Mental or physical fatigue, according to the National Institute of Neurological Disorders and Stroke. There is no known cause or cure.

Contributor: Erin Jensen, USA TODAY

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