Amy Schumer reveals intimate side effects of ‘colonoscopy gone wrong’

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Amy Schumer is opening up about her feelings after a routine medical procedure apparently went awry.

The 44-year-old “Trainwreck” star spoke with “Not Thin But Not Fat” host Amanda Hirsch about feeling “happier than ever” during a surprise appearance at a Dear Media event on May 17, according to Us Weekly and E. news. But Schumer acknowledged that she has also experienced some struggles.

“Actually, I feel like I just had a botched colonoscopy, so I’m not really in the mood for sex,” she reportedly told Hirsch.

Schumer filed for divorce from her husband of seven years, Chris Fischer, in January, but reportedly declined to provide further details.

According to the National Institute of Diabetes and Digestive and Kidney Diseases, doctors “recommend screening for colorectal cancer starting at age 45 unless you have health problems or risk factors that increase your chances of developing colorectal cancer.”

Schumer’s comedy often relies on a sense of “deliberate over-information,” but she has never shied away from sharing her health struggles with fans. In January 2025, the comedian revealed that he had been diagnosed with Cushing’s syndrome.

In an interview with “Call Her Daddy” host Alex Cooper, Schumer said internet trolls helped her realize there might be something wrong with her health. Haters online commented on the swelling on her face, a clear sign of a hormonal disorder.

Cushing’s syndrome is a rare condition that occurs when there is too much cortisol in the body, Dr. Divya Yogi Molen, medical director of the Cleveland Clinic’s Pituitary Center, previously told USA TODAY. Cortisol, known as the “stress hormone,” influences how the body deals with stress and plays an important role in maintaining physical health.

In September 2021, more than two years after giving birth to Schumer and ex-husband Chris Fischer’s son Gene, Schumer underwent surgery to address symptoms of endometriosis. She shared on Instagram that both her uterus and appendix were removed during the surgery due to the aggressive nature of the case.

Contributed by Anna Kaufman and Adrianna Rodriguez, USA TODAY

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