College Football Week 12 Predictions, Betting Odds and Today’s Schedule

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Week 12 of the 2025 college football season could be an opportunity to make some big changes to the College Football Playoff field.

Of the 25 teams ranked in the U.S. LBM Coaches Poll, 23 are scheduled to play games this weekend, including a total of two games in the SEC’s top 10 that could shake up the entire 12-team field. No. 4 Alabama (8-1, 6-0 SEC) will play No. 10 Oklahoma State (7-2, 3-2 SEC), and No. 5 Georgia (8-1, 6-1) will play No. 10 Texas (7-2, 4-1).

Another important matchup is No. 9 Notre Dame vs. No. 23 Pittsburgh, which is attracting enough attention that ESPN’s “College GameDay” is returning to Pittsburgh for the first time in 20 years.

As has been the case all season, any team could be on alert on Saturday. Penn State nearly defeated No. 2 Indiana last week, but No. 14 Vanderbilt avoided an upset by Auburn in overtime.

Here’s an early look at picks, predictions and odds for every Saturday Week 12 game on the 2025 college football schedule.

College football week 12 game predictions, picks

Odds are current as of Sunday, November 1, courtesy of BetMGM. 9

1st place Ohio State University vs UCLA

  • date: Saturday, November 15th
  • time: 7:30pm ET
  • position: Ohio Stadium (Columbus, Ohio)
  • Spread: Ohio State University -31.5

Prediction: Ohio State 42, UCLA 10

2nd place Indiana vs. Wisconsin

  • date: Saturday, November 15th
  • time: 12:00 PM ET
  • position: Memorial Stadium (Bloomington, Indiana)
  • Spread: Indiana -30.5

Prediction: Indiana 38, Wisconsin 10

No. 3 Texas A&M vs. South Carolina

  • date: November 15th (Sat)
  • time: Noon Eastern Standard Time
  • position: Kyle Field (College Station, Texas)
  • spread: Texas A&M -18.5

Prediction: Texas A&M 34, South Carolina 16

No. 4 Avandose vs. Naui vs. and Oklahoma

  • date: November 15th (Sat)
  • time: 3:30 PM ET
  • position: Bryant-Denny Stadium (Tuscaloosa, Alabama)
  • spread:Alabama-7

Preprust: Alabama 30, Okahahahahah 28

No.5 Georgia vs. No.10 Texas

  • date: November 15th (Sat)
  • time: 7:30pm (Eastern Standard Time)
  • position: Sanford Stadium (Athens, Georgia)
  • spread: Georgia -6

Prediction: Georgia 31, Texas 24

No.7 Ole Miss vs. Florida

  • date: November 15th (Sat)
  • time: 7pm ET.
  • position:Vought-Hemingway Stadium (Oxford, Mississippi)
  • spread: Ole Miss -13.5

Prediction: Ole Miss 42, Florida 17

No. 8 Texas Tech vs. Central Florida

  • date: November 15th (Sat)
  • time: 3:30 PM ET
  • position: Jones AT&T Stadium (Lubbock, Texas)
  • spread: Texas Tech -23.5

Prediction: Texas Tech 34, UCF 14

good. 9 Notre Dame vs. No. 23 Pittsburgh

  • date: November 15th (Sat)
  • time: Noon Eastern Standard Time
  • position: Acresure Stadium (Pittsburgh, Pennsylvania)
  • spread: Notre Dame -10.5

Prediction: Pittsburgh 34, Notre Dame 30

  • date: November 15th (Sat)
  • time: 3:30 PM ET
  • position: Alumni Stadium (Chestnut Hill, Massachusetts)
  • spread: Georgia Tech -16.5

Prediction: Georgia Tech 49, Boston College 14

No. 12 BYU vs TCU

  • date: November 15th (Sat)
  • time: 10:15 PM ET
  • position: LaVell Edwards Stadium (Provo, Utah)
  • spread:BYU -5.5

Prediction: TCU 28, BYU 21

No. 15 Utah vs. Baylor

  • date: November 15th (Sat)
  • time: 7pm ET.
  • position:McLean Stadium (Waco, Texas)
  • spread: Utah -8.5

Prediction: Utah State 30, Baylor State 28

No.16 Miami vs. North Carolina State University

  • date: November 15th (Sat)
  • time: 7:30pm (Eastern Standard Time)
  • position:Hard Rock Stadium (Miami Gardens, Florida)
  • spread: Miami -14.5

Prediction: Miami 31, NC State 18

No. 17 Michigan vs. Northwestern

  • date: November 15th (Sat)
  • time: Noon Eastern Standard Time
  • position: Wrigley Field (Chicago)
  • spread: Michigan -10

Prediction: Northwestern 23, Michigan 20

No.18 Southern California vs. Iowa

  • date: November 15th (Sat)
  • time: 3:30 PM ET
  • position: Los Angeles Memorial Coliseum (Los Angeles)
  • spread:USC-6.5

Prediction: Iowa 30, USC 24

No.19 Virginia vs. Duke

  • date: November 15th (Sat)
  • time: 3:30 PM ET
  • position:Wallace Wade Stadium (Durham, North Carolina)
  • spread: Duke -6.5

Prediction: Duke 27, Virginia 21

No.20 Tennessee vs. New Mexico State University

  • date: November 15th (Sat)
  • time: 4:15 PM ET
  • position: Neyland Stadium (Knoxville, Tennessee)
  • spread: Tennessee -38.5

Prediction: Tennessee 49, New Mexico 14

No.22 Cincinnati vs Arizona

  • date: November 15th (Sat)
  • time: Noon Eastern Standard Time
  • position:Nippert Stadium (Cincinnati, Ohio)
  • spread: Cincinnati -6

Prediction: Cincinnati 34, Arizona 31

No.24 Missouri vs. Mississippi State University

  • date: November 15th (Sat)
  • time: 7:45 PM ET
  • position: Memorial Stadium (Columbia, Missouri)
  • spread: Missouri -6.5

Prediction: Missouri 30, Mississippi State 20

  • date: November 15th (Sat)
  • time: 3:30 PM ET
  • position: Bridgeforth Stadium (Harrisonburg, Virginia)
  • spread: James Madison -20.5

Prediction: James Madison 35, App State 14

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