Best Beds for the NFL Weekly 5: Why I Like the Eagles and Lions on Sundays
Need help making your pick before Sunday? Lorenzo Reyes shares their best bets for their fifth week game.
The Los Angeles Rams host a San Francisco 49ers team that was hurt and abused in a “Thursday Night Football” clash between NFC West rivals.
The 49ers will run out on the offensive side of the ball for Thursday’s game. Starting quarterback Brock Purdy (TOE) misses the contest after returning from injury in week 4, starting receivers Ricky Pearsall (knee) and Jauan Jennings (rib rib/ankle).
Bith George Kittle (Hamstring) and Brandon Aiyuk (ACL Recovery) also stand by, with 49ers backup quarterback Mac Jones having to work with the skeleton weapons crew in divisional battles. He believes he’s leaning heavily towards Christian McCaffrey as a backfield outlet while receiver Kendrick Bourne and tight end Jake Tong try to help as much as he can.
The Rams are far healthier than the 49ers and will likely rely on Pukanakua to continue their attacks. The 24-year-old currently leads the league with catches (42) and receiving yards (503), usually working well in the “TNF” game, averaging 122.3 yards in three career games on Thursday.
Like last Thursday night’s game between the Seattle Seahawks and the Arizona Cardinals, the winner will find himself sitting alone above the NFC West for at least a few days.
USA Today Sports brings live game updates, highlights and more. Please check below.
San Francisco used a large dose of Christian McCaffrey to drive the 49ers opening drive. He took up 40 yards with five touches (two catches, three carry). However, quarterback Mac Jones discovered a tight ending jocking in the middle opens wide due to a six-yard touchdown pass.
Eddy Pineiro’s extra points attempt is good, with the 49ers taking a 7-0 lead at 10:09 and going into the first quarter.
The 49ers quarterback was buried for an injured block pardy and began a 4-4 match for 71 yards.
Los Angeles won a coin toss and chose to postpone it to the second half. Rams kicker Josh Carty energized a knuckleball-style kick to start the game, and 49ers returner Skyy Moore groped it out. After it bouncing back in the air, Moore surrounded it and the 49ers offense began a drive on his own 28-yard line.
- Kickoff time8:15pm
The Rams will host the 49ers for a crash at Sophie Stadium on Thursday, October 2nd at 8:15pm. The game begins at 5:15pm local time, and will begin for the second consecutive week in which the NFC West team faced “Thursday night football.”
San Francisco: KTVU (FOX 2)
Amazon Prime will air a Rams vs. 49ers matchup in week 5. The streaming giant owns the rights to the NFL’s “Thursday Night Football” broadcast package, and usually crews from Al Michaels (play by play), Kirk Herbstreit (Game Analyst) and Kaylee Hartung (Sideline Reporter) meet the game.
NFL fans who watch the game nationwide will need an Amazon Prime subscription to access Thursday’s game. However, the NFL has an arrangement for local market viewers from Los Angeles and San Francisco teams to watch the game simultaneously on local TV stations.
Below, let’s take a look at the local channels that broadcast the contest.
- Los Angeles: KTTV (FOX 11)
- San Francisco: KTVU (FOX 2)
Watch “Thursday Night Football” with your Prime Video Subscription
Rams Pass Rusher follows a great rookie season with an impressive start to 2025. Throughout the four games, poetry has 18 pressures per PFF. He graded out at 91.8 overall, with his 91.5 pass rush grade ranking fifth overall in the NFL (minimum 20% of 157 pass rush snaps).
Colby Parkinson played his best game of 2025 in Los Angeles’ fourth week victory at Indianapolis as the Rams’ tight end in his second season. The former Seahawk caught both targets for 17 yards.
The 49ers are 3-1 in the season and are first tied up at NFC West.
The Rams are not surprised when they enter a division matchup with the 49ers.
- QB Stetson Bennett IV
- Te Tyler Higbee
- Ol Rob Havenstein
- ol beautiful rimmer
- DeJuan Johnson
49ers’ inactive vs. ram
The 49ers are back from a grass toe injury without a block pardy from quarterback. Here are the remaining inactivity of tonight’s game:
- QB Block Purdy
- RB Jordan James
- WR Jordan Watkins
- WR Ricky Pearsall
- WR Jaw Angennings
- DL Robert Beal
- LB Nick Martin
Los Angeles Rams vs. San Francisco 49ers predictions, picks
All six members of the USA Today Sports expert pick panel believe the Rams will beat the 49ers on “TNF.” Below are the expected scores for the contest:
- Jarrett Bell: Rams 31, 49ers 24
- Nick Blinkerhoff: Rams 27, 49ers 23
- Chris Bunbaka: Rams 27, 49ers 18
- Nate Davis: Rams 31, 49ers 23
- Tyler Dragon: Rams 24, 49ers 20
- Michael Middlehurst Schwartz: Rams 31, 49ers 17
2025 Los Angeles Rams Schedule
Los Angeles Rams Records 2025
The Rams are 3-1 in the season and are tied to No. 1 at NFC West.
